Figure 3.
Figure 3. Cytolytic activities of CD94-expressing cells expanded from G-PBMCs against the patients' leukemic cells. (A) Cytolytic activities of HLA-matched donor CD94-expressing cells expanded from 8 different donor G-PBMCs against K562 cells (□), the patients' own leukemic cells (▦) , and autologous PHA blasts (). (B, C) Cytolytic activities of allogeneic third-party CD94-expressing cells expanded from 4 different donor G-PBMCs against K562 cells, the patients' primary leukemic cells, autologous PHA blasts, and allogeneic PHA blasts. Addition of anti–HLA class I mAbs (W6/32, 20μg/mL) (▪). MFIs of HLA class I on target cells are indicated. The data represented are the means ± SDs (effector-to-target ratio is 10:1).

Cytolytic activities of CD94-expressing cells expanded from G-PBMCs against the patients' leukemic cells. (A) Cytolytic activities of HLA-matched donor CD94-expressing cells expanded from 8 different donor G-PBMCs against K562 cells (□), the patients' own leukemic cells (▦) , and autologous PHA blasts (). (B, C) Cytolytic activities of allogeneic third-party CD94-expressing cells expanded from 4 different donor G-PBMCs against K562 cells, the patients' primary leukemic cells, autologous PHA blasts, and allogeneic PHA blasts. Addition of anti–HLA class I mAbs (W6/32, 20μg/mL) (▪). MFIs of HLA class I on target cells are indicated. The data represented are the means ± SDs (effector-to-target ratio is 10:1).

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