Figure 1.
Characteristics of WHIM patients. (A) Pedigrees of 3 patients with WHIM syndrome. (B) Scheme of CXCR4 structure and localization of mutations in patients P1, P2, and P3. GαI indicates G protein; the dark gray dots correspond to threonine residues; and the light gray dots correspond to serine residues. Positions of proximal and terminal amino acid in the C-tail of the molecule are indicated.

Characteristics of WHIM patients. (A) Pedigrees of 3 patients with WHIM syndrome. (B) Scheme of CXCR4 structure and localization of mutations in patients P1, P2, and P3. GαI indicates G protein; the dark gray dots correspond to threonine residues; and the light gray dots correspond to serine residues. Positions of proximal and terminal amino acid in the C-tail of the molecule are indicated.

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