Caspase inhibitor, Z-VAD(oMe)-FMK, prevents EGCG from down-regulating Mcl-1 and XIAP. Primary CLL B cells were pretreated with Z-VAD(oMe)-FMK (25 μM) for 30 minutes prior to the EGCG treatment for 24 hours. Protein extract (50 μg) was prepared and then subjected to SDS-PAGE (7.5%). The blots were blotted with the antibody of interest. Data shown are representative of 2 different experiments.