Figure 4.
IAC-1 has no effect on the platelet-collagen interaction. (A) Binding of washed platelets (3 × 105/μL) to collagen-coated wells in the presence of various concentrations of either IAC-1 (•) or Gi9 (▪) under static conditions. Error bars indicate the SEMs of 3 independent experiments. (B) Collagen-induced aggregation of washed platelets (3 × 105/μL), preincubated for 5 minutes with buffer, IAC-1 (10 μg/mL), or Gi9 (10 μg/mL). Aggregation was induced by 12 μg/mL human collagen type I (arrow). Data are representatives of 3 independent experiments.
