Pedigree of the QPD family. Men (squares) and women (circles) in 7 generations are shown. Solid symbols indicate affected participants (n = 23). Symbols containing an X indicate additional individuals known or presumed to have QPD on the basis of results of previous testing (n = 6), a history of typical QPD bleeding problems, or documented QPD transmission to offspring. Open symbols containing dots indicate unaffected individuals who participated in the study (n = 104). Open symbols without dots indicate other known or presumed unaffected family members. Partners are shown for women who had children with several individuals. Children of unknown sex are shown as diamonds (representing known or unknown numbers of individuals, as indicated).