MBCD decrypts TF in HEK293 cells and primary human dermal fibroblasts. HEK293 cells or human dermal fibroblasts were incubated at 10⁷/mL in cell buffer alone or cell buffer containing indicated concentrations of octyl glucoside, MBCD, α-cyclodextrin, or cholesterol-enriched MBCD. Rates of fVIIa/TF were determined by using a 5-μL aliquot of treated cells and expressed as a ratio to the rate determined by using cells treated with buffer alone. Data presented are means ± SDs for at least 5 determinations. ^*P < .01 versus buffer-treated cells. Maximal decryption with octyl glucoside was not statistically different from maximal decryption with MBCD indicated by NS.