Systemic inflammation in tc-ptp^-/- mice. (A) Light micrograph of myocardium of tc-ptp^-/- mouse 21 days old (D21) featuring interstitial edema, prominent interstitial mononuclear cellular infiltrate, and patchy myocyte degeneration and necrosis. (B) Light micrograph of gastric mucosa of tc-ptp^-/- mouse age D21 featuring dense mononuclear cellular infiltrate with patchy destruction of gastric epithelium. (C) Light micrograph of parotid gland of tc-ptp^-/- mouse age D21 demonstrating mononuclear cellular infiltrate. (D) Light micrograph of kidney and adjacent adipose tissue of tc-ptp^-/- mouse age D21 demonstrating mononuclear cellular infiltrate in the superficial renal cortex and adjacent perinephric adipose tissue. (E-H) Light micrographs of myocardium (E), gastric mucosa (F), parotid gland (G), and kidney (H) of tc-ptp⁺/^- mice age D21 showing normal histology. All panels stained with H and E; original magnification × 200 for all panels.