Inhibition of expression of α-globin by overexpression of truncated c-met mRNA. Stage 33/34 embryos were stained for α-globin RNA by in situ hybridization. (A,C,E) Lateral views. (B,D,F) Ventral views. Embryos were injected at the 8-cell stage with either (A-B) LacZ mRNA into 2 ventral-vegetable blastomeres (control), (C-D) truncated c-met mRNA into 2 ventral-vegetable blastomeres, or (E-F) truncated c-met mRNA into 2 dorsal-vegetable blastomeres. Yellow arrowheads indicate the absence of α-globin expression, compared with control.