Figure 2.
![Figure 2. Body weight–normalized warfarin doses, INR, and unbound oral clearance for S-warfarin (CLpo,u[S]) in white and Japanese patients with different sequence patterns in the 5′-flanking region of the CYP2C9 gene. Horizontal bars represent mean values of the respective groups. (A) White patients; (B) Japanese patients. Filled circles represent the patients with SNPs in the coding region of the CYP2C9 gene: Japanese patients with homozygous CYP2C9*3 and white patients with homozygous CYP2C9*2 or CYP2C9*1/*11 (see detailed combinations of the promoter and coding region SNPs in Figure 1). *P < .05 and **P < .01 for comparisons between the patients with different sequence patterns in the 5′-flanking region of CYP2C9 in Japanese patients.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/103/8/10.1182_blood-2003-07-2521/6/zh80080460010002.jpeg?Expires=1724949131&Signature=lqGV1Rgx~4CgFdVjcC9xJAdsXDN7ua-kCp6EZkdV20nty7hR7Z0UNOOS9GMj6DNHAuUbEdcLpF~9loK7wncbw~1C5OUYKW4AEd5Pb~OJqBmH7sQE2~M~Qy1nrBQnIJ0ODwZ76ouuClYFaGJD76HBKxgWbGTW7xWQYudhvIazjMPZruAzxch7txX30v1avBmVnY37RP1apoOlrTZtCiKWUN4Gaif-tiFKDrb2ylJssZvAVhLwMosakqKyty~noSARPvV9X~voVQRAwmw42gk3TNfcmlnAZrl5wEMY7l~iU4k1WGsDy7k1dCEK~lzDapndH9v4w~vxRnzSgP~zNr6IfA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Body weight–normalized warfarin doses, INR, and unbound oral clearance for S-warfarin (CLpo,u[S]) in white and Japanese patients with different sequence patterns in the 5′-flanking region of the CYP2C9 gene. Horizontal bars represent mean values of the respective groups. (A) White patients; (B) Japanese patients. Filled circles represent the patients with SNPs in the coding region of the CYP2C9 gene: Japanese patients with homozygous CYP2C9*3 and white patients with homozygous CYP2C9*2 or CYP2C9*1/*11 (see detailed combinations of the promoter and coding region SNPs in Figure 1). *P < .05 and **P < .01 for comparisons between the patients with different sequence patterns in the 5′-flanking region of CYP2C9 in Japanese patients.
