Figure 5.
Figure 5. The interaction between uninfected erythrocytes and parasite antigens does not suppress IFN-γ responses to PPD. IFN-γ (pg/mL) was assayed in 6-day supernatants of PBMCs cultured with uninfected red blood cells (equivalent to 1:10 dilution of whole blood) plus 5 μg/mL PPD; 5 × 105/mL iRBCs; 5 × 105/mL lysed schizonts (PfSL); PPD plus iRBCs; or PPD plus PfSL. Data from 5 donors are shown. The dotted line indicates the LLD for the IFN-γ ELISA (125 pg/mL).

The interaction between uninfected erythrocytes and parasite antigens does not suppress IFN-γ responses to PPD. IFN-γ (pg/mL) was assayed in 6-day supernatants of PBMCs cultured with uninfected red blood cells (equivalent to 1:10 dilution of whole blood) plus 5 μg/mL PPD; 5 × 105/mL iRBCs; 5 × 105/mL lysed schizonts (PfSL); PPD plus iRBCs; or PPD plus PfSL. Data from 5 donors are shown. The dotted line indicates the LLD for the IFN-γ ELISA (125 pg/mL).

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