CD45^- cell evolution. (A) Evolution of percentage CD45^- 5T2MM cells during disease progression. MM cells were detectable above background levels by flow cytometry 4 weeks after tumor injection and were phenotyped for CD45 expression. Percentages of CD45^- MM cells in the total myeloma population are shown. Each point represents mean value of 3 mice ± SD. (B) Evolution of the MVD in function of percentage CD45^- 5T2MM cells. MVD represents the number of blood vessels per 0.20 mm². Percentages of CD45^- MM cells in the total myeloma population are shown. Each point represents mean value of 3 animals ± SD.