In vivo effect of rhHAPO on hematopoiesis in normal mice. The 16 mice in each group received a daily subcutaneous injection of rhHAPO at doses of 10 μg for 7 days. Shown are the effect of rhHAPO on the number of bone marrow nucleated cells (A); the numbers of the CD34⁺, Sca-1⁺, and c-kit⁺ cells in murine bone marrow (B); and the number of circulating white blood cells (C), platelets (D), and red blood cells (RBCs) (panel E), as well as the percentage of reticulocytes (F) on day 14 after rhHAPO administration. Data are represented as the mean ± SD. ^*P < .05 versus control.