The role of TRAF6 in LPS-stimulated endothelial cells. LPS-induced activation of TRAF6 results in activation of multiple downstream signaling pathways involved in inflammation. Additionally, TRAF6 routes parallel apoptotic (JNK) and antiapoptotic (PI3K) signals that are triggered by LPS. However, LPS-induced ERK activation in endothelial cells is TRAF6 independent.