Figure 2.
Thrombin-catalyzed fibrin polymerization. Polymerization of fibrinogen (0.27 mg/mL) was initiated with thrombin (0.05 U/mL) and the change in turbidity at 350 nm was followed with time. Representative polymerization curves of normal (▪), γN308K (•), γN308I (▴), and γN308A (⋄) fibrinogens in the absence of added CaCl2 (A) and in the presence of 1 mM CaCl2 (B) are shown.
