Survival of donor and various third-party primary skin grafts on mice receiving anti-CD8, 3 Gy TBI, BM transplants, and anti-CD154. Recipient mice were grafted 1 day after BMT with both donor and third-party skin grafts. All chimeric mice accepted donor skin grafts for more than 100 days (B10.A). Mice that received fully MHC- and minor antigen-mismatched grafts (A.SW) rejected these grafts within 20 days (n = 3). Chimeras that received grafts that shared donor MHC and were mismatched for minor histocompatibility antigens (A/J) were all rejected by day 55 (n = 7). MHC class I-mismatched grafts (B10.BR) sharing donor MHC class II were rejected by 4 of 5 chimeras within 80 days.