Cumulative proportion of clinical worsening among the cohort of patients (Kaplan-Meier estimate) and the subgroups. The estimate curve of all patients (A) shows in MACE-positive patients a higher probability of clinical worsening than that of MACE-negatives. The same results are obtained also by the estimate curves of the subgroup of patients with a platelet count lower than 50 × 10⁹/L at enrollment (B) and considering only the 38 patients with the chronic form of ITP (C).