Figure 6.
Figure 6. Effect of VEGF analogs and their corresponding receptors on neutrophil adhesion to HUVECs and role of P-selectin translocation. HUVECs were pretreated with rPSGL-Ig (A), SU1498 (B), or either with a GST-Ex7 or GST (C) for 15 minutes prior to the addition of neutrophils (1 × 105) and to the stimulation of confluent HUVECs with VEGF analogs (10–9 M, 7.5 minutes). Data are means ± SEM of 6 to 12 experiments; ***P ≤ .001 as compared to DPBS and ††P ≤ .01, †††P ≤ .001 as compared to corresponding VEGF analogs.

Effect of VEGF analogs and their corresponding receptors on neutrophil adhesion to HUVECs and role of P-selectin translocation. HUVECs were pretreated with rPSGL-Ig (A), SU1498 (B), or either with a GST-Ex7 or GST (C) for 15 minutes prior to the addition of neutrophils (1 × 105) and to the stimulation of confluent HUVECs with VEGF analogs (10–9 M, 7.5 minutes). Data are means ± SEM of 6 to 12 experiments; ***P ≤ .001 as compared to DPBS and ††P ≤ .01, †††P ≤ .001 as compared to corresponding VEGF analogs.

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