Effect of atorvastatin, simvastatin, fenofibrate, and Wy 14643 on IL-1β-induced huCRP expression. (A) Groups of huCRPtg mice (n ≥ 5) received a chow diet containing atorvastatin (At) at a low dose (LD; 0.01% [wt/wt]) or at a high dose (HD; 0.1% [wt/wt]), or vehicle (Con) for 3 weeks. Mice intraperitoneally received IL-1β either at a low dose (8.3 × 10⁴ U/mouse) or at a high dose (2.5 × 10⁵ U/mouse). (B) As in panel A but mice were fed 0.1% (wt/wt) simvastatin (Sim). (C) As in panel A but mice were fed 0.1% (wt/wt) fenofibrate (FF). (D) As in panel A but mice were fed 0.03% (wt/wt) Wy 14643 (WY). HuCRP levels were determined in tail blood which was collected 18 hours after IL-1β stimulation. Data represent means ± SEM. ^*P < .05 compared with control.