Effect of atorvastatin, simvastatin, fenofibrate, and Wy 14643 on plasma cholesterol and basal huCRP expression. (A) Groups of huCRPtg mice (n ≥ 5) received a chow diet containing a low dose (LD; 0.01% [wt/wt]) of atorvastatin (At) or vehicle control (Con) for 4 weeks. Plasma cholesterol was determined in tail blood and data are expressed as means ± standard deviation (SD). (B) As in panel A but mice received a high dose (HD; 0.1% [wt/wt]) of atorvastatin. (C) Plasma huCRP levels of mice were determined in tail blood at t = 0 and t = 4 weeks and data are expressed as means ± SEM. (D) As in panel A but mice received a dose of 0.1% (wt/wt) simvastatin. (E) As in panel C. (F) As in panel A but mice received 0.1% (wt/wt) fenofibrate (FF) or 0.03% (wt/wt) Wy 14643. (G) As in panel C. Statistical significant difference compared with control animals is indicated by ^*P < .05. ns = not significant.