Figure 2.
Figure 2. Hepc1 quantification and nonheme iron concentration in livers of 8-week-old mice. Hepc1 quantification (A) and nonheme iron concentration (B) are as in Figure 1 but in liver samples from 8-week-old mice. Results are expressed as mean ± SD for n animals (NS indicates nonsignificant). Results in panel B were normalized according to the sex. The sex ratio (female-male) for hepatic iron was 1.44 for Hfe-/-Usf2+/- mice, 1.45 for Hfe-/-Usf2+/+ mice, 1.28 for Hfe+/-Usf2+/- mice, and 1.24 for Hfe+/-Usf2+/+ mice. The Kruskal-Wallis test for hepc1 quantification was P < .01 (mean rank: Hfe-/-Usf2+/-, 11.55; Hfe-/-Usf2+/+, 13.67; Hfe+/-Usf2+/-, 23.64; Hfe+/-Usf2+/+, 31.57) and for nonheme iron concentration P < .0001 (mean rank: Hfe-/-Usf2+/-, 29.80; Hfe-/-Usf2+/+, 21.92; Hfe+/-Usf2+/-, 10.71; Hfe+/-Usf2+/+, 4.29). *P < .01; **P < .001; ***P < .0001.

Hepc1quantification and nonheme iron concentration in livers of 8-week-old mice.Hepc1 quantification (A) and nonheme iron concentration (B) are as in Figure 1 but in liver samples from 8-week-old mice. Results are expressed as mean ± SD for n animals (NS indicates nonsignificant). Results in panel B were normalized according to the sex. The sex ratio (female-male) for hepatic iron was 1.44 for Hfe-/-Usf2+/- mice, 1.45 for Hfe-/-Usf2+/+ mice, 1.28 for Hfe+/-Usf2+/- mice, and 1.24 for Hfe+/-Usf2+/+ mice. The Kruskal-Wallis test for hepc1 quantification was P < .01 (mean rank: Hfe-/-Usf2+/-, 11.55; Hfe-/-Usf2+/+, 13.67; Hfe+/-Usf2+/-, 23.64; Hfe+/-Usf2+/+, 31.57) and for nonheme iron concentration P < .0001 (mean rank: Hfe-/-Usf2+/-, 29.80; Hfe-/-Usf2+/+, 21.92; Hfe+/-Usf2+/-, 10.71; Hfe+/-Usf2+/+, 4.29). *P < .01; **P < .001; ***P < .0001.

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