Fibrinolytic capacity and TAFIa generation in 20210A carriers. Fibrinolysis was studied by a turbidimetric assay using a tissue factor–induced plasma clot exposed to 25 ng/mL exogenous t-PA. (A), lysis time; (B), fibrinolytic response to CPI (50 μg/mL) expressed as CPI ratio (lysis time in the absence of CPI divided by the lysis time in the presence of CPI); (C), TAFIa generated in the clot lysis mixture 30 minutes after the start of the experiment. TAFIa activity was measured as CPI-sensitive carboxypeptidase activity and is expressed as the percentage of total TAFI activity of pooled normal plasma. The horizontal bars represent the means of the groups. The differences were assessed by the Mann-Whitney test.