Figure 5.
Figure 5. E-selectin inhibits proliferation and induces apoptosis of HPCs from PSGL-1–/– mice. Bone marrow lineageneg Sca-1+ c-KIT+ (LSK) sorted cells from PSGL-1–/– and wild-type control mice were cultured for 5 days in the presence of 6 cytokines (3611FTS) on wells coated with either BSA (□), rmu P-selectin–Fc at 1800 sites/μm2 (▦), or rmu E-selectin–Fc at 550 sites/μm2 (▪). Concentrations of viable cells and percentage of apoptotic cells are indicated in panels A and B, respectively. Mean values ± SD of 2 experiments made in triplicate. *Statistically different (P < .05) from BSA control groups.

E-selectin inhibits proliferation and induces apoptosis of HPCs from PSGL-1–/– mice. Bone marrow lineageneg Sca-1+ c-KIT+ (LSK) sorted cells from PSGL-1–/– and wild-type control mice were cultured for 5 days in the presence of 6 cytokines (3611FTS) on wells coated with either BSA (□), rmu P-selectin–Fc at 1800 sites/μm2 (▦), or rmu E-selectin–Fc at 550 sites/μm2 (▪). Concentrations of viable cells and percentage of apoptotic cells are indicated in panels A and B, respectively. Mean values ± SD of 2 experiments made in triplicate. *Statistically different (P < .05) from BSA control groups.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal