AML1 mutations in MDS/AML, AML (M0), and FPD/AML. Items in bold show the identical mutation. Boxes outlined with solid lines indicate N-terminal missense/insertion mutations that replace amino acid residues in three loops directly contacting DNA. Boxes outlined with dashed lines indicate N-terminal nonsense/frame-shift mutants resulting in similar truncated forms of the protein. — indicates previously not reported. ^* indicates mutant belonging to Type b (described in “Discussion”); †, mutant belonging to Type a-1 (described in “Discussion”); ‡, mutant belonging to Type a-2 (described in “Discussion”); §, mutant belonging to Type a-3 (described in “Discussion”); and ¶, mutant belonging to Type a-4 (described in “Discussion”).