Stasis-induced thrombosis and vascular remodeling in the carotid artery of mutant mice. Representative sections through the ligated carotid artery of mutant mice, obtained 4 weeks after ligation. H&E staining, cell nuclei appear dark. Neointima formation but no thrombosis in wild-type (A) and fibrinogen-deficient (D) mice. Neointima formation and severe thrombosis in thrombomodulin-deficient mice (B-C). Enhanced (E) and in some cases occlusive stenosis/intimal hyperplasia in hyperfibrinogenemic mice (F). Note the absence of organized thrombi in Hifib animals. Original magnification, × 40.