Figure 1.
In vitro characterization of JF959602. (A) Structure of JF959602. (B) JF959602 inhibited SFLLRN-induced P-selectin surface expression on human platelets with an IC50 of 0.4 μM. (C) JF959602 was found to inhibit human platelet PDE3A (•) with an IC50 of 15 nM. No substantial inhibition of recombinant human PDE2 (○) or human platelet PDE5 (×) by the compound was observed. Error bars represent mean ± 1 SD (n = 3).
