Schematic of CY metabolism. A fraction of CY is excreted unchanged in urine. The remaining prodrug (CY) is converted to DCCY or oxidized to HCY by CYP2B6, 3A4, and 2C9. HCY is further degraded to alternative metabolites (shown here are ketoCY, HPPM, and CEPM). Relative quantities of metabolites measured in fluconazole and itraconazole recipients are shown.