Effect of modulation of BUBR1 expression on hematopoiesis. Modulation of BUBR1 expression affected hematopoiesis in vitro. (A) Bone marrow cells from BUBR1^+/– and wild-type mice were assayed for CFU-Mk's (P < .001, n = 12) as described in “Materials and methods.” (B) Bone marrow cells from BUBR1^+/– and wild-type mice were assayed for CFU-Es (P < .0005, n = 8). Error bars represent means ± standard deviation.