American Society of Hematology

Figure 1.

$Figure 1. Kinetics analysis of EBs generated from wild-type (Runx1+/+), heterozygous (Runx1+/–), and deficient (Runx1–/–) ES cells. (A) FACS analysis of Flk1 and c-Kit expression on Runx1+/+, Runx1+/–, and Runx1–/– EB-derived cells. The days of differentiation are indicated. Numbers in each quadrant represent the percent of total population in each fraction. Number of blast colonies (B), primitive erythroid colonies (C), macrophage colonies (D), and secondary EB colonies (E) generated by Runx1+/+, Runx1+/–, and Runx1–/– EB cells. Days of differentiation are indicated. Bars represent standard error of the mean number of colonies from at least 3 cultures. (F) Expansion of cell numbers following differentiation of Runx1+/+, Runx1+/–, and Runx1–/– ES cells.$

Kinetics analysis of EBs generated from wild-type (Runx1⁺^/⁺), heterozygous (Runx1^+/–), and deficient (Runx1^–^/^–) ES cells. (A) FACS analysis of Flk1 and c-Kit expression on Runx1^+/+, Runx1^+/–, and Runx1^–/– EB-derived cells. The days of differentiation are indicated. Numbers in each quadrant represent the percent of total population in each fraction. Number of blast colonies (B), primitive erythroid colonies (C), macrophage colonies (D), and secondary EB colonies (E) generated by Runx1^+/+, Runx1^+/–, and Runx1^–/– EB cells. Days of differentiation are indicated. Bars represent standard error of the mean number of colonies from at least 3 cultures. (F) Expansion of cell numbers following differentiation of Runx1^+/+, Runx1^+/–, and Runx1^–^/^– ES cells.

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