Figure 4.
Figure 4. Chemotaxis of PDCs in response to adenosine is mediated by the A1 receptor. (A) Migration of PDCs cultured overnight in the presence of IL-3 in response to 1 μM of the A1, A2a or A3 receptor agonists CHA, DPMA, or IB-MECA, respectively. (B) Migration of PDCs toward 100 μM adenosine in the absence or presence of 10 μM of the A1,A2a, orA3 receptor antagonists DPCPX, CSC, or MRS 1220, respectively. Data represent mean ± SEM of 3 to 4 different experiments. *P < .05.

Chemotaxis of PDCs in response to adenosine is mediated by the A1 receptor. (A) Migration of PDCs cultured overnight in the presence of IL-3 in response to 1 μM of the A1, A2a or A3 receptor agonists CHA, DPMA, or IB-MECA, respectively. (B) Migration of PDCs toward 100 μM adenosine in the absence or presence of 10 μM of the A1,A2a, orA3 receptor antagonists DPCPX, CSC, or MRS 1220, respectively. Data represent mean ± SEM of 3 to 4 different experiments. *P < .05.

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