Calcium signaling of PDCs in response to adenosine and specific adenosine receptor agonists. Calcium transients in PDCs cultured overnight with IL-3 (A-B) or IL-3 plus CD40L for 48 hours (B) in response to adenosine or the specific adenosine receptor agonists, CHA, DPMA, and IB-MECA (each 1 μM), was analyzed by flow cytometry. After establishing a baseline for 10 seconds, reagents were added at the indicated concentrations. Representative data of 4 different experiments are shown.