Figure 5.
Figure 5. Effect of anti–β2-integrinAb M18/2 on angiogenesis and leukocyte infiltration. M18/2 or a isotype-matched control mAb was added to Matrigel and injected intraperitoneally every other day, as described in “Materials and methods.” (A) Quantitative evaluation of neovessels infiltrating Matrigel after treatment with SnPP, VEGF, or VEGF plus SnPP in presence of M18/2 or a control mAb. The results are expressed as percentage ± SE of the vessel area with respect to the total Matrigel area. (B) Quantitative evaluation of inflammatory cells infiltrating Matrigel counted in hematoxylin and eosin–stained sections. The results are expressed as the mean ± SE of cells/field (× 400). Four mice were used per condition in each experiment. ANOVA with Dunnett multicomparison test was performed between control Ab and M18/2 (*P < .05).

Effect of anti–β2-integrinAb M18/2 on angiogenesis and leukocyte infiltration. M18/2 or a isotype-matched control mAb was added to Matrigel and injected intraperitoneally every other day, as described in “Materials and methods.” (A) Quantitative evaluation of neovessels infiltrating Matrigel after treatment with SnPP, VEGF, or VEGF plus SnPP in presence of M18/2 or a control mAb. The results are expressed as percentage ± SE of the vessel area with respect to the total Matrigel area. (B) Quantitative evaluation of inflammatory cells infiltrating Matrigel counted in hematoxylin and eosin–stained sections. The results are expressed as the mean ± SE of cells/field (× 400). Four mice were used per condition in each experiment. ANOVA with Dunnett multicomparison test was performed between control Ab and M18/2 (*P < .05).

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