American Society of Hematology

Figure 5.

$Figure 5. Representative images of firm adhesion of washed human platelets to a fibrinogen-coated membrane in a perfusion flow chamber under high shear. Platelets were either (A) unstimulated (control) or (B) stimulated with recombinant fractalkine (rhCX3C; 1 μg/mL). The proadhesive effect was blocked by either (C) antagonism of rhCX3C (AF537; 100 μg/mL; 30 min) or by (D) disruption of CX3CR1-mediated signaling with PTX (0.4 nM; 45 min). Single spots resemble artifacts due to the setting of the microscope. They are identically existent on every tracing shown (as indicated by the arrow). Original magnification, × 20.$

Representative images of firm adhesion of washed human platelets to a fibrinogen-coated membrane in a perfusion flow chamber under high shear. Platelets were either (A) unstimulated (control) or (B) stimulated with recombinant fractalkine (rhCX₃C; 1 μg/mL). The proadhesive effect was blocked by either (C) antagonism of rhCX₃C (AF537; 100 μg/mL; 30 min) or by (D) disruption of CX₃CR1-mediated signaling with PTX (0.4 nM; 45 min). Single spots resemble artifacts due to the setting of the microscope. They are identically existent on every tracing shown (as indicated by the arrow). Original magnification, × 20.

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