A model for a growth inhibitory pathway activated by ICSBP in myeloid cells. Bcr/Abl activates c-Myc expression to stimulate cell growth ICSBP induces the Blimp-1 and METS genes, which contribute to repression of the c-Myc gene and presumably other growth control genes. Bcr/Abl may down-regulate ICSBP expression to achieve efficient mitogenic transformation in CML.