Effects of L19mTNFα on biodistribution of ¹²⁵I-L19-IL2 in tumor-bearing mice. The %ID/g (mean ± SD) of tumor (A) and blood (B) and tumor-to-blood ratios of the %ID/g (C) at different times after intravenous injection of 0.5 μg/g ¹²⁵I-L19-IL2 alone (⋄) and in combination with 0.7 pmol/g unlabeled L19mTNFα (♦) or unlabeled TN11mTNFα (▵). (D) Effects on tumor growth of the treatments with L19mTNFα combined to L19-IL2. F9 tumor growth curves after 2 intravenous (IV) injections with PBS, 0.7 pmol/g L19mTNFα, 1.0 μg/g L19-IL2, and with the combinations of 1.0 μg/g L19-IL2 and 0.7 pmol/g L19mTNFα or TN11mTNFα. F9 tumor volume is expressed in cm³ (mean ± SD). The intravenous injections were carried out at the times indicated by arrows.