(A) Overall survival in patients with high levels of MRP3 and in patients with low levels of MRP3. The 75th percentile was used as cutoff for high and low expression. N indicates number of patients; OS, overall survival; and SE, standard error. Log-rank test:P = .002. (B) Same analysis as in panel A, but restricted to patients who were treated in the more recent studies ALL-BFM 90/95 and 2000. Log-rank test: P = .071.