Persisting migration of CD4⁺blasts in the presence of protease inhibitors. Migration in 3D collagen (A-B) and multicomponent matrices (C) in the absence or presence of protease inhibitor cocktail. (A) Digitized paths of 40 cells at orthotopic position (2-hour tracking period; 1 representative of 3 independent experiments). (B-C) Steady-state velocity and percentage of migrating CD4⁺ T cells in collagen (B) and collagen copolymerized with hyaluronan and chondroitin sulfate (C). Data show the means of time-dependent population parameters ± SDs for 3 independent experiments (120 cells).