Inosine inhibits ConA-induced liver injury by an IL-10-independent mechanism. IL-10⁺/+ (A) and IL-10^-/- (B) mice were injected with ConA (20 mg/kg), inosine (100 mg/kg), or both, and serum ALT was determined 24 hours after injection. This figure shows that inosine inhibited ConA-induced ALT regardless of the lack of IL-10 production in IL-10^-/- mice. Representative results from one of 3 separate experiments.