Figure 4.
Figure 4. Effects of various drugs on mitochondria with or without caspase inhibitor IDN-1529. OCI-AML3 cells were treated with 2 μM Ara-C, 500 ng/mL Dox, 10 ng/mL vincristine (Vinc), or 50 ng/mL paclitaxel for up to 48 hours, with or without the caspase inhibitor IDN-1529 (Inh I) (20 μM). (A) Immunoblotting analysis of cytochrome c, Smac, and Omi releases from mitochondria. (B) Changes in mitochondrial membrane potential determined by CMXRos and MitoTracker green. cntl indicates control; R1, cells maintaining Δψm; R2, cells partially losing Δψm; R3, cells losing Δψm. Results are expressed as mean ± SE.

Effects of various drugs on mitochondria with or without caspase inhibitor IDN-1529. OCI-AML3 cells were treated with 2 μM Ara-C, 500 ng/mL Dox, 10 ng/mL vincristine (Vinc), or 50 ng/mL paclitaxel for up to 48 hours, with or without the caspase inhibitor IDN-1529 (Inh I) (20 μM). (A) Immunoblotting analysis of cytochrome c, Smac, and Omi releases from mitochondria. (B) Changes in mitochondrial membrane potential determined by CMXRos and MitoTracker green. cntl indicates control; R1, cells maintaining Δψm; R2, cells partially losing Δψm; R3, cells losing Δψm. Results are expressed as mean ± SE.

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