Fancc and p53 cooperate in the progression of tumorigenesis in mice. Mice that were deficient for Fancc and Trp53 were monitored long term (1.5 years) for tumors (107 total mice). Mice were killed at the observance of tumors or significant morbidity. A Kaplan-Meier plot of percent survival (y-axis) as a function of time (x-axis) is shown. The genotypes are indicated next to each plot. Statistical significance of differences in survival between the groups was assessed by log rank analysis: P < .0001 comparing Fancc^+/+Trp53^-/- to Franc^-/-Trp53^-/-, and P < .005 comparing Fancc^+/+Trp53^+/- to Fancc^-/-Trp53^+/-.