Cytokine profile of cultured spleen T cells from irradiated and reconstituted mice (n = 4 to 5 per group). Th1 (IFN-γ) and Th2 (IL-4, IL-5, and IL-10) cytokine production in cultured spleen T cells 24 hours (for IL-4) or 48 hours (for IFN-γ, IL-5, and IL-10) following stimulation with con A. P = .02 for IFN-γ, IL-4, and IL-5; P = .77 for IL-10. We found a significant increase in IFN-γ (A), IL-4 (B), and IL-5 (C) production in spleen T cells from dnTGFBRII mice compared with controls. There was no difference in IL-10 production (D) between the 2 groups.