Inflammatory content of atherosclerotic lesions. Representative photomicrographs showing atherosclerotic lesions in the aortic sinus of control (A,C) or CD2-dnTGFBRII (B,D) LDLr KO mice. CD3 staining was detected by staining with antimouse CD 3-ϵ (small red spots in A and B). MHC class II expression in the lesions was detected by staining with antimouse MHC class II (small red spots in C and D). Original magnification, × 200. (E) Quantitative analysis of CD3-positive (T lymphocytes) and MHC class II-positive cells in the atherosclerotic plaques of CD2-dnTGFBRII (n = 8) and control (Ct; n = 7) mice. Four to 5 sections per animal were analyzed for each immunostaining. Results are expressed as number of positive cells per mm² lesion area (numbers above bars ± SEM). P < .05 for T lymphocytes; P = .01 for MHC class II.