FeCl₃ carotid artery thrombosis study. Analysis of FeCl₃ injury times to initial occlusion and whether stable occlusion occurred are shown for various study conditions. At the right for each study condition are 2 representative thrombosis curves. At the top of the figure are WT mice that were littermate controls, demonstrating that under the conditions of injury, all of the WT animals rapidly developed stable occlusive thrombi. Below are FVIII^null mice treated with various doses of hB^-FVIII immediately prior to an FeCl₃ injury to their carotid artery. At the bottom, similar studies were done with line no. 38 transgenic animals on an FVIII^null background, with 4 representative curves shown. NA indicates not applicable.