Mutant N-Ras induces expression of known Ras/MAPK targets. Five genes were found to be virtually absent in NIL controls (average difference of < 200) and significantly induced in the mutant N-ras-transfected samples (average difference of > 1000). Three of these genes were solely induced by N-ras activating mutation. Among these ETV5 has been shown to be a target of Ras/MAPK signaling.