Comparison of TEM of PLP-specific T cells across bEndI1/2.1 or bEndI1.1 expressing the ICAM-1/ICAM-2 chimera I1EI2C. TEM of SJL.PLP2 across TNF-α-stimulated and unstimulated bEndI1/2.1 or across bEndI1.1 with their TEM across the respective daughter endothelioma lines transduced with wild-type (wt) ICAM-1 or the ICAM-1/ICAM-2 chimera I1EI2C is shown. The chimeric I1EI2C was found to be unable to reconstitute TEM to wild-type levels. Bars represent mean ± SD (n = 3). Significant differences in I1EI2C versus wt are marked as follows: ^**P < .01, very significant; ^***P < .001, extremely significant.