Histopathology of liver after hepatic infusion of the adenoviral HD vector AdFTC/cFIX/ChMAR. Representative histologic findings in liver samples obtained from hemophilia B dogs G11 and G21 5.5 months and 2 months after adenoviral administration, respectively. Hematoxylin and eosin staining of formalin-fixed liver sections from hemophilia B dog G11 (A-D) and dog G21 (E-H). (A) Liver 1, G11. (B) Liver 1, G11. (C) Liver 2, G11. (D) Liver 2, G11. (E) Liver 1, G21. (F) Liver 1, G21. (G) Liver 2, G21. (H) Liver 2, G21. Liver 1: caudate; liver 2: right medial. Original magnifications: × 100 (A,C,E,G); × 400 (B,D,F,H)