3-Cl-AHPC and tRA inhibition of growth and the induction of apoptosis in human leukemia cell lines. M07e, KG-1, and HL-60R cells were seeded in RPMI 1640 supplemented with 5% FBS and incubated overnight; varying concentrations of 3-Cl-AHPC or tRA were added and the cells harvested at various times. The results represent the mean of 3 independent experiments, with the variation between the experiments being < 10% if error bars are not shown. Error bars represent standard deviations. (A) The 3-Cl-AHPC inhibition of proliferation of M07e cells. (B) The 3-Cl-AHPC induction of apoptosis in M07e cells. (C) The tRA inhibition of M07e proliferation. (D) The 3-Cl-AHPC (1 μM) and tRA (1 μM) induction of apoptosis in KG-1 cells. (E) The 3-Cl-AHPC (1 μM) and tRA (1 μM) induction of apoptosis of HL-60R cells.