Effect of clodronate liposomes on plasma nucleosome and DNA levels. Plasma nucleosome (A) and DNA (B) levels were measured after the administration of clodronate liposomes at 2 doses. Clodronate liposome doses are given in microliters. Data represent the mean (± SEM) of 3 mice. Empty liposomes (not shown) did not produce changes in levels of nucleosomes and DNA.