WT Shp-2 is expressed in Shp-2^R cells. (A) Schematic diagram of WT Shp-2 protein and resultant mutant Shp-2 protein after targeted deletion of the Shp-2 allele. (B) Protein lysate from WT, Shp-2^Δ, and Shp-2^R1, and Shp-2^R2 cells was immunoprecipitated and blotted with anti-SH-PTP2C (C18), which recognizes both the WT Shp-2 and Shp-2^Δ46-110.