Effects of recombinant human activated protein C (rhAPC) on endotoxin (LPS)–induced changes in white blood cell counts. Healthy male volunteers received rhAPC (24 μg/kg per hour for 8 hours; ▪) or placebo (○) intravenously starting 2 hours before LPS challenge (2 ng/kg). rhAPC did not alter white blood counts of neutrophils (top graph), monocytes (middle graph), or lymphocytes (bottom graph). P < .001 versus baseline for both groups; and P = ns between groups; mean ± SEM.