Effects of recombinant human activated protein C (rhAPC) on endotoxin (LPS)–induced endothelial, platelet, or neutrophil activation. (A) E-selectin. (B) P-selectin. (C) Elastase. (D) Platelet counts. Healthy male volunteers received rhAPC (24 μg/kg per hour for 8 hours; ▪) or placebo (○) intravenously starting 2 hours before LPS challenge (2 ng/kg). P < .001 versus baseline for both groups, and P = ns between groups; mean ± SEM.